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Index > Protein center > FDXR(Gene name) > Human
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  • FDXR (Gene name),
  • NADPH:adrenodoxin oxidoreductase, mitochondrial (Protein name ),  ADRO_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    FDXR(ADXR);
    Protein name:
    NADPH:adrenodoxin oxidoreductase, mitochondrial(AR;Adrenodoxin reductase);
    Alternative:
    Ferredoxin--NADP(+) reductase(Ferredoxin reductase);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer. Interacts directly with FDX1.
    Function:
    Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
    Subcellular Location:
    Mitochondrion matrix
    Protein Attributes:
    Sequence length:
    491
    Sequence:
    50:
    MASRCWRWWG | WSAWPRTRLP | PAGSTPSFCH | HFSTQEKTPQ | ICVVGSGPAG | 
    100:
    FYTAQHLLKH | PQAHVDIYEK | QPVPFGLVRF | GVAPDHPEVK | NVINTFTQTA | 
    150:
    HSGRCAFWGN | VEVGRDVTVP | ELREAYHAVV | LSYGAEDHRA | LEIPGEELPG | 
    200:
    VCSARAFVGW | YNGLPENQEL | EPDLSCDTAV | ILGQGNVALD | VARILLTPPE | 
    250:
    HLERTDITKA | ALGVLRQSRV | KTVWLVGRRG | PLQVAFTIKE | LREMIQLPGA | 
    300:
    RPILDPVDFL | GLQDKIKEVP | RPRKRLTELL | LRTATEKPGP | AEAARQASAS | 
    350:
    RAWGLRFFRS | PQQVLPSPDG | RRAAGVRLAV | TRLEGVDEAT | RAVPTGDMED | 
    400:
    LPCGLVLSSI | GYKSRPVDPS | VPFDSKLGVI | PNVEGRVMDV | PGLYCSGWVK | 
    450:
    RGPTGVIATT | MTDSFLTGQM | LLQDLKAGLL | PSGPRPGYAA | IQALLSSRGV | 
    491:
    RPVSFSDWEK | LDAEEVARGQ | GTGKPREKLV | DPQEMLRLLG | H
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    SMR:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human AR
    Cat.:
    E15390b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human AR
    Cat.:
    E15390m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human AR
    Cat.:
    E15390r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human AR
    Cat.:
    E15390h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AR
    Cat.:
    U15390b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AR
    Cat.:
    U15390m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AR
    Cat.:
    U15390h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AR
    Cat.:
    U15390r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human AR
    Cat.:
    P15390Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human AR
    Cat.:
    P15390Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human AR
    Cat.:
    P15390Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human AR
    Monoclonal Antibody for Human AR
    Monoclonal Antibody for Human AR
    Monoclonal Antibody for Human AR
    Monoclonal Antibody for Human AR
    Protein for Human AR
    Protein for Human AR
    Protein for Human AR
    Protein for Human AR

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    References
    1. 1.
      "Human adrenodoxin reductase: two mRNAs encoded by a single gene on chromosome 17cen-->q25 are expressed in steroidogenic tissues."
      Solish S.B. , Picado-Leonard J. , Morel Y. , Kuhn R.W. , Mohandas T.K. , Hanukoglu I. , Miller W.L.
      Proc. Natl. Acad. Sci. U.S.A.85:7104-7108(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SHORT AND LONG);VARIANT GLN-123
    2. 2.
      "Cloning and sequence of the human adrenodoxin reductase gene."
      Lin D. , Shi Y. , Miller W.L.
      Proc. Natl. Acad. Sci. U.S.A.87:8516-8520(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      NIEHS SNPs program
      Submitted (2005-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-7; GLN-123; VAL-213; LEU-248; TRP-251; CYS-301; MET-345; SER-352 AND ALA-472
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4; 5; 6 AND 7);VARIANT GLN-123
      tissue: Adrenal gland.
      tissue: Caudate nucleus.
      tissue: Testis.
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT)
      tissue: Lung.
    6. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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